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The Influence of Anaphylactic Shock on Fluid in the Peritoneal Cavity

I. Influence Upon Quantity of Fluid Absorbed and Upon of the Fluid

Department of Bacteriology and Hygiene, St. Louis University School of Medicine

Abstract

The factors concerned in the production of the edema in a local anaphylactic reaction are, generally speaking, unknown. In many respects the lesion is similar to that produced by an injection of an irritant substance. It is, however, certain that the substance responsible for the development of the edema is not a toxic or highly irritant substance, when introduced, regardless of what changes it may undergo in the local area in the sensitized animal some time after the injection. It is evident that the action is dependent upon the cells in the area in contact with the antigen; that these cells have in some manner been changed so that they react abnormally—either qualitatively or quantitatively—upon the introduction of the antigen. Exactly what these changes may be is not clear but it has long been maintained that a changed permeability of the cells is one factor.