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Immunological Studies in Tubercolosis

II. Further Observations on Skin Hypersensitiveness in Experimental Tubercolosis

Research and Clinical Laboratory Trudeau Sanatorium, New York

Abstract

Within the last few years the problem of skin hypersensitiveness has again assumed a prominent part in the field of experimental tuberculosis. There has been no great departure as far as the theory and the method employed in these investigations from that held and employed a decade or so ago; however, teh whole tendency has been to follow the older methods of investigations, only attacking it from a little different angle.

A very careful search of literature reveals only a few papers which deal strictly with the production of skin hypersensitiveness with dead tubercle bacilli. The lack of interest in carrying on such inverstigations was probably due to the authorithative statements appearing from time to time that true tubercullin skin hypersensitiveness could not be set up in a normal animal with anything else but living tubercle bacili.