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The Chemical Basis of Immunological Specificity

Department of Pathology, University of Chicago, and the Ohio S. A. Sprague Memorial Institute

Abstract

So remarkable are the manifestations of specificity, so exquisitely delicate are many of the immunological reactions exhibiting specificity, and so wonderfully minute are the traces of proteins that may suffice to demonstrate it, that it has commnly been assumed taht specificity must depend on chemical or physical differences far too slight to be detected by other than immunological methods. The most recent and extensive reference book on the subject of immunity (Zinsser's Infection and Resistance, 3d Edition, 1923, p. 86) makes the statement that the manifestation of specificity.

points to an exquisite chemical difference between the protein substances which constitute the bacterial cell bodies or their metabollic products.