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Immunity in Rocky Mountain Spotted Fever

Department of Pathology, Harvard University Medical School

Abstract

The behavior of the virus in the tick and in laboratory animals is contrasted. The fact that there are so few organisms in the blood may be the reason why the virus in this situation is not amenable to attenuation. It has been shown that in tick tissues and in the tissues of guines-pigs the virus ame be attenuated by drying in the cold, and that after keeping for from five to thirty days at a below zero temperature, the tissue is no longer virulent but will produce immunity.

Several methods of using combinations of virus and immune serum have been tried. The most effcetive seems to be where virus is given in rather large dose and allowed to grow for twenty-four hours when a dose of serum is given to stop the infection. Another method which is successful under limited conditions is teh giving of large doses of mixtures of virus and serum. It is shown that an immunity may be achieved which equals that following an attack of the disease. The same mixtures heated to 60° for twenty minutes have been ineffective.