HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Opie, E. L. Search for Related Content PubMed Articles by Opie, E. L.

Inflammatory Reaction of the Immune Animal to Antigen (Arthus Phenomenon) and Its Relation to Antibodies

Henry Phipps Institute, University of Pennsylvania, and the Department of Pathology, Washington University

Abstract

When horse serum is injected into the subcutaneous tissue of a rabbit it is absorbed within a few hours with no evident inflammatory reaction but if the injection is repeated at intervals of several days the animal reacts with acute inflammation at the site of injection. This phenomenon was first noted by Arthus (1) and has been designated by his name. After the fourth subcutaneous injection the skin about the injection becomes red and there is a soft edematous infiltration which disappears after two or three days. After the fifth injection infiltration is firmer and persists five or six days. After the sixth injection severe injury to the edematous subcutaneous tissue is evident and a solid white mass resembling pus is formed. In most instances after the seventh injection the skin undergoes necrosis. The gangrenous area separates slowly from the surrounding tissue and cicatrization occurs after several weeks.