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Iso-Hemagglutinins in Rabbits

From the Bussey Institution and the Massachusetts State Antitoxin and Vaccine Laboratory

Abstract

The attempt has been made by various investigators to throw light upon the problem of the inheritance of blood groups in man by studying their behavior in other animals, but the results obtained are conflicting. In man, simple Mendelian factors seem to be involved, although the correct interpretation of the data on record is by no means certain.¹ In looking for blood groups in other mammals to form an experimental basis for a genetic study, no satisfactory groupings have been established. Some investigators have claimed to have found groupings, but most of those who have looked for them have found none.

In 1907, Hektoen reported that he was unable to find isoagglutinins in the serum of rabbits, guinea-pigs, dogs, horses, and cattle. He used in each instance the serum and corpuscles of 10 to 20 animals.

In 1911, Ottenberg and Friedman presented evidence to show that blood groups exist in rabbits and steers.

Footnotes

¹ For details concerning the investigations on inheritance in relation to human blood groups, see Von Dungern and Hirschfeld, 1910: Learmonth, 1920; Weszecsky 1920; Keynes, 1921; Ottenberg, 1921, 1922, 1923; Tebbutt and McConnel. 1922; Buchanan, 1922; Jervell, 1923; Lattes, 1923.