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Antibody Responses Induced by Aqueous and Emulsified Influenza Virus Vaccines in Mice Exposed Daily to X-Rays¹

From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

Hemagglutination-inhibiting (HI) antibody responses to aqueous and emulsified mineral oil adjuvant influenza virus vaccines were compared at 15, 27 and 43 days after vaccination in mice exposed to daily x-irradiation (except Sundays) beginning 1 day before vaccination. At each bleeding HI levels induced by the adjuvant were higher in similarly irradiated mice than those induced by an aqueous vaccine containing the same amount of antigen. Moreover, HI responses in the irradiated mice injected with emulsified vaccine were equal or higher at each bleeding than those in mice injected with aqueous vaccine but not irradiated. The findings were interpreted as indicating that the adjuvant effect of emulsified vaccine was reduced, but not abolished, by repeated exposures to x-ray.

Footnotes

¹ This investigation was conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, and was supported by the Office of the Surgeon General, U. S. Army, Washington, D. C.