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Antibody Formation in the Rat

II. Agglutinin Response to Soluble Flagellin from Salmonella Typhosa

From the Department of Pathology and the Argonne Cancer Research Hospital, the University of Chicago,¹ Chicago, Illinois

Abstract

The role of dose of antigen, the route of its injection, and the presence or absence of the spleen in the primary and secondary agglutinin response of the rat have been studied using purified, soluble flagellin from Salmonella typhosa as antigen. Within the range studied, injection of larger quantities of antigen generally resulted in higher circulating agglutinin levels in both the primary and secondary response. Compared with the results obtained when particulate flagella was used as antigen, the effect of splenectomy and the effect of route of injection were less marked. The general pattern of agglutinin response was also different after administration of the two forms of antigen. Possible reasons for these differences are discussed.

Footnotes

¹ Operated by the University of Chicago for the United States Atomic Energy Commission.