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The Immunologic Behavior of Baby Pigs

I. Production of Antibodies in Three-Week-Old Pigs¹

From the Department of Veterinary Pathology and Hygiene, College of Veterinary Medicine, University of Illinois, Urbana, Illinois

Abstract

Colostrum-deprived pigs failed to produce antibody to diphtheria toxoid inoculated intraperitoneally at 3 weeks of age, and responded only slightly to tetanus toxoid administered in the same manner. The immunologic deficiency of colostrum-deprived pigs was overcome by the following procedures, listed in order of decreasing efficiency: a) by suckling of colostrum, b) by administration of diluted hyperimmune serum of swine and horse origin, c) of immune swine serum, d) and of normal serum from older, colostrum-deprived pigs. Removal of specific antibodies from the hyperimmune swine serum resulted in loss of the antibody-stimulating activity of the serum. The results are consistent with the natural selection hypothesis of antibody formation proposed by Jerne.

Footnotes

¹ These studies were aided by Contract Nonr-1834 (37) (NR 103-509) between the Office of Naval Research, Department of the Navy, and the Board of Trustees of the University of Illinois.

² Present address: College of Veterinary Medicine, Iowa State University, Ames, Iowa.

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