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The Journal of Immunology, 1962, 89: 775-781.
Copyright © 1962 by The American Association of Immunologists, Inc.
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Passive Anaphylaxis in Mice with Homologous Antiserum

II. Reactions due to Circulating and Tissue Antibody1

Perry E. Treadwell2 and A. F. Rasmussen, Jr.

From the Division of Virology, Department of Infectious Diseases, University of California Medical School, Los Angeles, California

Abstract

Study of anaphylaxis in the mouse produced by passive and reverse passive sensitization was undertaken. Groups of mice were sensitized with several levels of homologous antibodies and shocked with 1, 8 or 100 times the equivalence dose of antigen at intervals from immediately to 1 week after sensitization. The severity of the resulting anaphylactic reactions depended upon the amount of antibody injected, the amount of antigen injected and the interval between the sensitizing and shocking injections. A biphasic response was observed in both passive and reverse passive anaphylaxis; maximal reactivity occurred 0 to 2 hr and 48 to 168 hr after sensitization with minimal reactivity from 6 to 24 hr after sensitization. The following conclusions were deduced from this study: a) the anaphylactic reactivity depends upon the amount of precipitable antibody, and b) upon the antigen-antibody ratio of the complexes formed in vivo as well as in vitro; c) the anaphylactic reactivity in the first 24 hr after sensitization depends primarily upon the formation of antigen-antibody complexes in the circulation, and after 24 hr, on an antigen-antibody reaction outside of the circulation.

Footnotes

1 Supported in part by research grants from the National Institutes of Allergy and Infectious Diseases and of Mental Health, USPHS.

2 Postdoctoral trainee, Mental Health Training Program, USPHS 2M 6415. Present address, Department of Microbiology, Emory University, Atlanta.






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