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Studies of a Complement-Fixing Antigen from Group A Streptococcal L-Forms

II. Antibody Reactions of Naval Recruits in Streptococcal Outbreaks and Acute Rheumatic Fever¹

From the Naval Medical Research Unit No. 4, U. S. Naval Hospital, Great Lakes, Illinois

Abstract

In the complement fixation test a streptococcal L-form antigen was shown to react against patient sera in association with streptococcal infection. The per cent of men with L-form reactive sera increased concomitantly with increasing isolations of group A streptococci in the streptococcal epidemics of 2 successive years. The L-form antibody is associated with streptococcal infection, but is not group A specific. It is present in a very high proportion of patients with acute rheumatic fever, but tends to decline in titer during treatment and convalescence. A high degree of qualitative and quantitative correlation exists between the L-from CF antibody titer and the antistreptolysin O titer of naval recruits.

Footnotes

¹ From Research Project MR 005.09-1300.5, the Bureau of Medicine and Surgery, Navy Department, Washington, D. C. The opinions and Assertions expressed herein are those of the authors and cannot be construed as indicating endorsement or approval by the Navy Department or the Naval Service at large.

Presented in part before the May 1959 meeting of the Society of American Bacteriologists, St. Louis, Missouri, and the April 1961 meeting of the American Society for Microbiology, Chicago, Illinois.