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Plaques Produced by T2r Phage Particles Partly Neutralized by Normal and Immune Guinea Pig Sera

From the Tip Fakültesi, Mikrobiyoloji Enstitüsü, Universite Istanbul, Istanbul, Turkey

Abstract

Phage plated on agar medium produce plaques of a given size according to the properties of the phage and host strain. However, the size of the plaque depends upon the conditions of the environment, the composition and consistence of the medium. If these conditions are constant, phage particles of a given type produce plaques of the same size.

It has been observed that phage particles may, under certain conditions, give plaques that are smaller than normal. For instance, when phages active on a strain of Salmonella typhi Vi 4 were plated, they produced small plaques if exposed to considerable light (1). Moreover, it was demonstrated that T4 phage treated with immune serum taken early during immunization, in which period neutralized phage particles may reactivate, produced small plaques (2). In addition, following neutralization with high titer immune serum of T4, some of the active phage particles gave rise to small plaques (3).

Footnotes

¹ The author wishes to express his appreciation to A. Eisenstark, Kansas State University, for suggestions in the preparation of the manuscript.