HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Luecke, D. H. Articles by Sibal, L. R. Search for Related Content PubMed PubMed Citation Articles by Luecke, D. H. Articles by Sibal, L. R.

Enhancement by Endotoxin of the Primary Antibody Response to Bovine Serum Albumin in Chickens¹

From the Department of Microbiology, University of Illinois College of Medicine, Chicago, Illinois

Abstract

Purified lipopolysaccharide of Salmonella abortus equi (endotoxin) was shown to enhance the antibody response of chickens to a single, intravenous injection of bovine serum albumin. Simultaneous injection of 5 or 10 µg of endotoxin/kg body weight and bovine serum albumin markedly potentiated all phases of antibody synthesis. The induction period was shortened, antibody levels were several-fold greater and detectable serum antibodies persisted for longer periods than in animals given antigen alone. Enhancement was demonstrated when endotoxin was given 24 hr after, but not 24 hr before, antigenic stimulation. The results are discussed with respect to the animal species involved as well as the time interval between endotoxin and antigen administration.

Footnotes

¹ Supported in part by the Graduate College Research Fund, University of Illinois, Chicago, Illinois.