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The Journal of Immunology, 1962, 89: 496-504.
Copyright © 1962 by The American Association of Immunologists, Inc.
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Delayed Cutaneous Reactions in the Rat1

Martin H. Flax and Byron H. Waksman2

From the Edwin S. Webster Memorial Laboratory of the Department of Pathology and the Neurology Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts

Abstract

Typical delayed skin reactions to tuberculin were elicited in rats sensitized by footpad injection of killed tubercle bacilli in oil. Their similarity to classical delayed reactions in guinea pig or rabbit is demonstrated by their identical time course, characteristic histologic appearance and passive transfer with sensitized lymph node cells. Similar reactions were obtained after sensitization with Nocardia asteroides in oil, OT in incomplete Freund's adjuvant or BSA in complete adjuvant. These were indurated reactions made up largely of mononuclear infiltrates in the deep dermis and subcutaneous tissues, maximal at 24 to 48 hr. This location of the lesions is correlated with the distribution of vessels of venous type.

Footnotes

1 This study was supported by Grant No. E-1257 of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland and by USPHS Research Training Grant in Pathology No. 2G-192.

2 National Neurological Research Foundation Scientist.




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M. Axelrad and D. A. Rowley
Hypersensitivity: Specific Immunologic Suppression of the Delayed Type
Science, June 28, 1968; 160(3835): 1465 - 1467.
[Abstract] [PDF]


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