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The Journal of Immunology, 1962, 89: 490-495.
Copyright © 1962 by The American Association of Immunologists, Inc.
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On the Nature of the Precipitate in the Generalized Shwartzman Reaction1

A. Berken2 and M. Wolman

From the Department of Pathology, Government Hospital, Tel Hashomer, Israel

Abstract

Evidence has been presented which indicates that the generalized Shwartzman reaction in rabbits is primarily a consequence of the intravascular precipitation of serum proteins. These precipitable proteins are present in sufficient quantity in the normal animal to result in the generalized Shwartzman reaction soon after the other necessary conditions are invoked. Apparently, these conditions are the presence in the circulation of a sufficient amount of a precipitating substance and depression of reticuloendothelial system (RES) phagocytic function. The administration of relatively large amounts of a precipitating substance (Liquoid) seems to obviate the requirement for an exogenous RES depressant. Pretreatment with the RES depressant lipid, ethyl stearate, followed by the administration of a single dose of endotoxin results in the occurrence of the generalized Shwartzman reaction. The analogous effects of ethyl stearate and cortisone on the RES and their possible significance are discussed.

Footnotes

1 Supported in part by a grant from the National Council to Combat Blindness, Inc., New York, New York.

2 A Fight for Sight Research Fellow of the National Council to Combat Blindness, Inc., New York, New York.

Present address: Department of Medicine, Bronx Municipal Hospital Center, Bronx 61, New York.






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