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Homograft Reaction in Mouse Radiation Chimeras

I. Indirect Evidence for Graft-Anti-Host Activity

From the Biology Division, Oak Ridge National Laboratory, ^,2 Oak Ridge, Tennessee

Abstract

A graft-against-host homograft immune reaction could be detected when spleen cells from homologous chimeras were tested. This reaction was elicited only by spleen cells from 30-day-old chimeras in which F₁ hybrid mice were the irradiated hosts and parental strain mice the bone marrow donors. The significance of this finding was discussed in a tentative analysis of the problem of the immune status of radiation chimeras.

Footnotes

¹ This work was done while the investigator was visiting this laboratory from Italy.

² Operated by Union Carbide Corporation for the U. S. Atomic Energy Commission.