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The Journal of Immunology, 1962, 89: 400-407.
Copyright © 1962 by The American Association of Immunologists, Inc.

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Some Properties of an Inhibitor of Polyoma Virus Hemagglutination Isolated from Bovine Serum1

S. Halperen2, J. H. Schieble2, R. Mori3, S. Dinka and W. W. Ackermann

From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan

Abstract

One of the several substances found in bovine serum which prevent agglutination of erythrocytes by polyoma virus has been isolated. The kinetics of its action indicate it reacts with the virus to form a product whose stability only at low temperature closely resembles the virus-erythrocyte complex. Like the red cell receptor, it is a mucoprotein. Some of its chemical and physical characteristics, as well as its visualization in the electron microscope, are described.

Footnotes

1 Aided by a Grant from The National Foundation.

2 S. Halperen and J. H. Schieble are trainees under a training grant for microbiologists supported by the National Institute of Allergy and Infectious Diseases. Condensed in part from a dissertation submitted by J. H. Schieble to the Graduate School, The University of Michigan, in partial fulfillment of the requirement for the degree of Doctor of Philosophy.

3 R. Mori, from the School of Medicine, Kyushu University, Fukuoka, Japan, was a Fellow of the Rockefeller Foundation during 1960–1961.







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