HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Suter, E. Search for Related Content PubMed PubMed Citation Articles by Suter, E.

Hyperreactivity to Endotoxin in Mice Infected with BCG

Studies on the Role of Concomitant Infection¹

From the Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida

Abstract

The induction of hyperreactivity to bacterial endotoxin by BCG infection was studied in germfree mice and in mice chronically infected with Salmonella typhimurium. The results showed that infection of BCG in germfree and in chronically infected animals caused a similar increase in sensitivity to endotoxin. It is concluded from these experiments that concomitant infection is not a decisive factor in the emergence of endotoxin hyperreactivity during BCG infection. The experiments also indicated that germfree mice were almost equally resistent to BCG infection as were conventional animals.

Footnotes

¹ This investigation was supported by Grants E-3062(A) and E-3798 from the National Institute of Allergy and Infectious Diseases, USPHS.