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The Inhibition of Hemagglutinin Formation in Mice by Thioguanine¹

From the University of Oregon Medical School, Portland, Oregon

Abstract

Thioguanine at a dose of 2.5 mg/kg was shown to be an effective inhibitor of the primary hemagglutinin response in both mice and rabbits. Similarly, 6-MP at a level of 15 mg/kg, prevented the formation of sheep cell hemagglutinins in rabbits. In mice, evidence of suppression was obtained with doses of 2.5 mg/kg begun on the first and second day following antigenic stimulation; a single subcutaneous injection of 75 mg/kg of TG was also effective if administered during the same intervals. Prolongation of the induction phase and depression of established hemagglutinin titers were evident in mice receiving 75 mg/kg of TG 2, 4 and 8 days after primary immunization. Pretreatment with TG for 2 and 5 days prior to antigen injection was ineffective. The secondary hemagglutinin response in mice was also suppressed by TG, provided the drug was given during the first 2 days following antigenic stimulation.

Footnotes

¹ Supported by Grant E-2661 (C₂) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Services.