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Antibody Production and Transfer to Egg Yolk in Chickens¹

From the Departments of Pathology and Microbiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Abstract

The primary and secondary antibody responses of hens to bovine serum albumin (BSA) trace labeled with I¹³¹ and the rate of elimination of this antigen in control and immunized birds have been investigated. By determination of the antibody response of hens and the half-life of homologous -globulin, estimates were made of the rates of antibody production in hens. The efficiency of transfer of antibody to egg yolks was studied using both injected I¹³¹ trace-labeled homologous serum globulin and actively formed antibody against a heterologous serum protein and a viral antigen. The time relationships between appearance of serum antibody and its transfer to yolk have been established as well as the relation of this phenomenon to the early stages of embryologic development.

Footnotes

¹ This investigation was supported by the U. S. Public Health Service and Atomic Energy Commission.

² Present Address: Department of Medicine, Northwestern University Medical School, Chicago, Ill.

³ Present Address: Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif.

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