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Influence of Vaccination on Respiratory Coccidioidal Disease in Cynomolgous Monkeys¹

From the Naval Biological Laboratory, School of Public Health, University of California, Berkeley, California

Abstract

Five of ten Cynomolgous monkeys (Macaca irus) died and two were moribund within 9 months after respiratory infection with 200 coccidioidal arthrospores. None of seven animals previously vaccinated with formalinized spheruleendospore elements of the fungus succumbed to the above dose but one vaccinated animal challenged with approximately 400 arthrospores died within a 7-week period. It was demonstrated that both early and late roentgenographic changes in the lungs were less extensive in the vaccinated group than in the control group and these observations were in accord with pathologic findings at necopsy. The etiologic agent was recovered from the lungs of all surviving animals but histopathologic studies suggested that the parasite was contained more effectively within lesions in the vaccinated monkeys.

Footnotes

¹ This work was supported by the Bureau of Medicine and Surgery, United States Navy, and the Office of Naval Research, Washington, D. C., under a contract with the Regents of the University of California. Reproduction in whole or in part is permitted for any purpose of the United States Government.

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