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Formation of Antibody to Haptens

I. Primary and Secondary Responses to p-amino Benzoic Acid and Bovine -globulin in Chickens and Rabbits¹

From the Department of Bacteriology, University of Kansas, Lawrence, Kansas

Abstract

Intensive immunization of chickens and rabbits with unconjugated PABA produced no antibody response as measured by the passive hemagglutination reaction. Antibody to PABA was produced in response to a series of injections of BGG-p-azobenzoate in rabbits, and to a single injection in chickens. Anti-PABA and anti-BGG primary and secondary antibody responses were partially characterized. In chickens a single injection of BGG-p-azobenzoate induced anti-PABA antibody within 72 hr. The peak for both anti-PABA and anti-BGG occurred after 5 to 7 days. Following peak titers, anti-BGG titers decreased rapidly, but anti-PABA titers persisted for 70 days. The persistence of antihapten antibody was discussed.

Following primary immunization with BGG-p-azobenzoate, anamnestic responses were produced in rabbits and chickens with free PABA. Secondary responses to BGG and to homologous protein-hapten were also reported.

Footnotes

¹ This investigation was supported by Research Training Grant 2E-158 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service.

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