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Immunization against Parainfluenza Infections

Antigenicity of Egg Adapted Types 1 and 3

From the Department of Biologics Research, Chas. Pfizer & Co., Inc., Terre Haute, Indiana

Abstract

Following adaptation of strains of parainfluenza types 1 and 3 to embryonated eggs, antigenic comparisons were made with convalescent ferret sera and postvaccination human sera. Homotypic reactions evident with ferret sera were not confirmed by responses of man which indicated a close antigenic relationship between the Sendai and HA-2 strains of type 1 and also heterotypic crossing with type 3 strains, SF-3 and HA-1.

Vaccines prepared by formalin treatment of virus sedimented from infected egg fluids have been found to be safe and potent in adults, children and infants. Possible explanations have been discussed for the relative poor antigenicity of type 1 virus.