HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Celada, F. Articles by Carter, R. R. Search for Related Content PubMed PubMed Citation Articles by Celada, F. Articles by Carter, R. R.

The Radiosensitive Nature of Homograft-Rejecting and Agglutinin-Forming Capacities of Isolated Spleen Cells

From the Biology Division, Oak Ridge National Laboratory,² Oak Ridge, Tennessee

Abstract

The killing effect of P₁ on P₂ cells was studied in irradiated, immunologically inert (P₁ x P₂)F₁ recipient mice by determining the decrease of antirat agglutinins synthesized by P₂ cells. This technique was used to assess quantitatively the homograft-rejecting capacity of known numbers of isolated spleen cells and to study the radioinactivation of immune responses. The data show that the homograft-rejecting capacity is more radioresistant than the agglutinin-forming capacity. This fact shows that a difference exists at the active cell level between the two capacities, and suggests that either two somatic cell lines or two maturation and/or differentiation stages are responsible.

Footnotes

¹ Part of this work was performed during an National Institutes of Health postdoctoral fellowship.

Present address: Istituto di Genetica Medica, Università di Torino, Italy.

² Operated by Union Carbide Corporation for the U. S. Atomic Energy Commission.

This article has been cited by other articles:

				H. Friedman Inhibition of Antibody Plaque Formation by Sensitized Lymphoid Cells: Rapid Indicator of Transplantation Immunity Science, August 7, 1964; 145(3632): 607 - 609. [Abstract] [PDF]