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Observations on Incidence and Mechanism of Egg Insusceptibility to Trachoma Viruses¹

From the Department of Microbiology, University of California Medical Center, San Francisco, California

Abstract

In the fall of 1959 and the summer of 1960 there were periods of a few weeks when embryonated eggs failed to support the growth of trachoma and inclusion conjunctivitis viruses. Yolk sac material harvested from such insusceptible eggs and stored at -40°C for several months interfered with the lethal effect of trachoma virus challenge in susceptible eggs. Quantitation of these phenomena has been attempted and possible explanations proposed. During 1961 careful, frequent tests failed to reveal a period of insusceptibility. Eggs laid during and after a time of extreme heat appeared to be fully susceptible to psittacosis and trachoma viruses. Thus environmental heat and associated nutritional disturbances appear less promising as an explanation for egg insusceptibility than a transmissible, interfering agent.

Footnotes

¹ Supported by grants from the National Institutes of Health (B 604); the Burroughs Wellcome Fund, and the Committee on Research, University of California.

Taken in part from a thesis submitted by S. Chino to the Graduate Division of the University of California in fulfillment of the requirements for the M.A. degree.

² Post-sophomore fellow, National Institutes of Health, United States Public Health Service.