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Studies of Induction of Allergic Encephalomyelitis in Rats and Guinea Pigs without the Use of Mycobacteria¹

From the Department of Medicine, New York University School of Medicine, New York, New York

Abstract

Allergic encephalomyelitis (AE) may be induced in rats by sensitization to either homologous or heterologous (guinea pig) spinal cord plus incomplete adjuvant, lacking killed mycobacteria. The disease induced in this manner is comparable in all respects to that induced conventionally with spinal cord plus complete adjuvant, containing mycobacteria. Rats occasionally develop AE following a single injection of the heterologous spinal cord alone.

In contrast to rats, mycobacteria are important for induction of AE in guinea pigs. Guinea pigs sensitized to heterologous (rat) spinal cord plus incomplete adjuvant only occasionally exhibit clinical signs and/or lesions of the disease. None of the animals sensitized to homologous spinal cord plus incomplete adjuvant developed AE.

Implications of these observations with respect to pathogenesis of AE are discussed.

Footnotes

¹ Initial phases of this work were carried out in the Department of Microbiology, New York University School of Medicine, Under contract with Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland. Major portion of work supported by United States Public Health Service Grants B-1127 and B-3104.

² Recipient of Investigatorship of the Health Research Council of New York City.

³ Recipient of Medical Student Fellowship of the National Foundation.

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