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A Study of Passive Sensitization of Guinea Pigs with Antigen-Antibody Complexes¹

From the Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California

Abstract

Passive cutaneous anaphylaxis was induced at sites sensitized with antigen-antibody complexes in antigen excess and a subsequent injection of antigen. Seventeen guinea pig antisera, seven rabbit antisera and one mouse antiserum to two antigens, egg albumin and bovine plasma albumin, were studied.

1. Sensitization of guinea pig skin sites occurred with complexes prepared with guinea pig antisera at various antigen excess ratios. Complexes prepared with either rabbit antisera or the mouse antiserum did not sensitize.

2. A longer time of induction of PCA was required when antigen-guinea pig antibody complexes were employed than when equal amounts of free antibody were injected.

These results are interpreted to mean that antigen-guinea pig antibody complexes dissociate in vivo in guinea pigs. Rabbit complexes and mouse complexes appear not to dissociate in guinea pigs.

Footnotes

¹ Supported in part by U. S. Public Health Service Training Grant 2E-82.

Taken in part from a thesis to be submitted in partial fulfillment of the requirements for the Master of Arts degree.

² Work performed during the tenure of a fellowship from the Giannini Foundation.