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Studies on the Bacteriophage Neutralizing Activity of Serums

II. Comparison of Normal and Immune Phage Neutralizing Antibodies¹

From the Department of Serology, Division of Communicable Disease and Immunology, and Veterans Administration Central Laboratory for Clinical Pathology and Research, Walter Reed Army Institute of Research, Washington, District of Columbia

Abstract

Immunization of rabbits with T2 phage results in the early development of neutralizing Ab which, except for its elevated titer, is indistinguishable from the Ab present prior to immunization and designated as normal Ab. Subsequently, Ab is formed which occurs in an additional Cohn fraction and, in contrast to the C' dependence of normal or early immune Ab, is C' independent. Moreover, the addition of C' to phage neutralizing Ab is without effect upon the reactivation of neutralized phage. Finally, both normal and immune sera neutralize phage in accord with the percentage law.

Footnotes

¹ A preliminary report of this work was read at the 1960 meeting of the American Association of Immunologists (1).