HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hirata, A. A. Articles by Campbell, D. H. Search for Related Content PubMed PubMed Citation Articles by Hirata, A. A. Articles by Campbell, D. H.

Retention of Antigen in Neonatal and Older Chicks¹

From the National Cancer Institute, National Institutes of Health, Bethesda and Division of Chemistry and Chemical Engineering, California Institute of Technology,³ Pasadena, California

Abstract

The retention of S³⁵-labeled bovine serum albumin in organs of neonatal and older chicks was compared.

The injection of equivalent amounts of S³⁵-BSA (56 mg/kg body wt) resulted in a significantly higher uptake by the spleen of neonatal than of older chicks. The injection into neonatal chicks of a tolerance-eliciting dose of the antigen (1008 mg/kg body wt) resulted in a proportionally higher uptake by spleen.

Antigen incorporated in the livers of neonatal and older chicks disappeared at similar rates, whereas rates of disappearance from the spleen differed for the two groups indicating that the antigen retained in the spleen may be different qualitatively in neonatal chicks than in older chicks.

Footnotes

¹ Supported by Grant No. E-1355 from the National Institutes of Health.

² This work was conducted in part during the tenure of a National Science Foundation Postdoctoral Fellowship at California Institute of Technology.

³ Contribution No. 2787.