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Immunochemical Studies on Bacteriophage Deoxyribonucleic Acid

III. Specificity of the Antibodies¹

From the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts

Abstract

Several rabbit antisera to ruptured T₂, T₄ and T₆ bacteriophage contained antibodies to DNA. With all of the antisera, denatured DNA was more effective serologically than native DNA. Of 41 different DNA preparations tested with an antiserum to T₄ DNA, only DNA isolated from T₂, T₄ or T₆ bacteriophage fixed C'. The specificity of the antibodies as measured by cross-reactivity is described. The antigenic determinant groups of T-even bacteriophage DNA include, in part, the glucosyl residue of the DNA.

Footnotes

¹ Supported in part by grants from the American Cancer Society, the National Institutes of Health and the National Science Foundation. Publication No. 160 from the Graduate Department of Biochemistry, Brandeis University, Waltham, Mass.

² Postdoctoral Fellow in Neurochemistry.

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