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Effect of an Antibody against Complement on Resistance and Immunity¹

From the Department of Bacteriology, College of Medicine, State University of Iowa, Iowa City, Iowa

Abstract

1. An antibody prepared against mouse complement was used in mice to determine its effect on resistance and immunity.

2. Resistance was reduced to infections caused by Staphylococcus aureus and Streptococcus pyogenes, but not those caused by Salmonella typhimurium or species of the genus Pasteurella by the use of the anticomplement.

3. The anticomplement did not influence the adaptation rate of a strain of A² influenza virus to mice.

4. Active and passive immunity to infections caused by Diplococcus pneumoniae were reduced by anticomplement. Neutralization of tetanus toxin by specific antitoxin was unaffected. Active immunity against the A² influenza virus was not influenced by the antibody against complement.

Footnotes

Supported in part by a grant from the Office of Naval Research (Contract NONR-1509(01)).