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Protection Against Fatal Anaphylactic Shock with -Globulins in Guinea Pigs and Mice

From the Centre de Recherches Allergiques et Immunologiques, Institut National d'Hygiène, Association Claude Bernard, Chaire de Médecine Expérimentale du Collège de France, Paris, France

Abstract

The effects of -globulins originating from various animal species on fatal anaphylactic shock induced by passive sensitization have been investigated in guinea pigs and mice.

Human and rabbit -globulins completely protected guinea pigs against fatal anaphylactic shock when injected in adequate doses before or simultaneously with sensitization. However, -globulin was injected after passive sensitization, the protective effect decreased when the interval between sensitization and injection of -globulin was increased.

A similar effect of human -globulin was observed in Haemophilus pertussis-treated and passively sensitized mice.

The quantity of -globulin required to prevent fatal anaphylaxis was much higher in mice than in guinea pigs.

Horse and bovine -globulins were ineffective even in very high doses.

The significance and the possible mechanism of action of the -globulins are discussed.

Footnotes

¹ Present address, Hôpital Broussais, 96 rue Didot, Paris (14 ème), France.

² Postdoctoral Fellow (EF 12,239) from the Institute of Allergy and Infectious Diseases, United States Public Health Service.