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Quantitative Studies on Surface Phagocytosis¹

From the Department of Medical Microbiology, University of Wisconsin Medical School, Madison, Wisconsin

Abstract

Clotted human blood possessed greater phagocytic and bactericidal activity against encapsulated pneumococci and -hemolytic streptococci than did heparinized blood, evidently a manifestation of surface phagocytosis. The effect of a fibrin surface on the efficiency of the phagocyte in the presence of specific opsonin, as measured by the bactericidal effect, varied with experimental conditions; this effect was not great in either direction.

Footnotes

This study was supported in part by a grant from the Wisconsin Alumni Research Foundation.

² Present address: Department of Microbiology, Ohio State University, Columbus 10, Ohio.