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Specific Cation Effects with Antibody to a Hapten with a Positive Charge¹

From the Department of Biochemistry Research, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York

Abstract

The binding of homologous hapten by antibody to the positively charged p-azophenyltrimethylammonium ion was found to be decreased by inorganic cations but not by anions. This appears due to the competition of the cations with the hapten for the negative charge in the specific site of the antibody molecule.

The order of effect for singly charged cations is Cs⁺ > Rb⁺ > NH K⁺ > Na⁺ Li⁺, which is in the order of the ionic radii and the inverse order of the radius of the hydrated ions. For doubly charged cations the order is Ba⁺⁺ > Ca⁺⁺ > Mg⁺⁺.

Footnotes

This research was supported in part by Grant E-2342 from the National Institute of Allergy and Infectious Disease, National Institutes of Health, United States Public Health Service.