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The Journal of Immunology, 1962, 88: 595-599.
Copyright © 1962 by The American Association of Immunologists, Inc.

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Studies on the Effect of Complement on Anaphylaxis in the Mouse

Oscar L. Frick1, Claude Stiffel and Guido Biozzi

From the Centre de Recherches Allergiques et Immunologiques, Association Claude Bernard, Centre National de la Recherche Scientifique and Institut National d'Hygiène, Paris, France

Abstract

The reduction of hemolytic complement to 10% or less by human {gamma}-globulin aggregates and antigen-antibody complexes in mice has no effect on passive cutaneous anaphylaxis induced by homologous antibody.

In general anaphylaxis in mice treated with Hemophilus pertussis the decomplementation by human {alpha}-globulin aggregates has no effect, whereas the antigen-antibody decomplementation produces a significant protection which is probably due to a shocking effect from this treatment.

Footnotes

1 This investigation was carried out during the tenure of a Postdoctoral Fellowship (EF 12,239) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.







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