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Studies on the Production of Wassermann Reagin

From the Laboratory of Hygiene, Department of National Health and Welfare, Ottawa, Ontario

Abstract

Antigens for the VDRL microflocculation test have been prepared containing: a) a synthetic substitute for cardiolipin, b) a synthetic substitute for natural lecithin, and c) synthetic substitutes for both cardiolipin and lecithin. Reagin-like antibodies were produced when the floccules formed by mixing each of these with syphilitic serum were injected into rabbits. Results are given for dimyristoyl glycerophosphoric acid as a substitute for cardiolipin and dioleoyl lecithin as a substitute for naturally occurring lecithin.

The relation of these findings to the formation of reagin in syphilitic infection is discussed.