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The Serologic Sequelae of an Influenza A-2 Epidemic Modified by Intercurrent Vaccination in an Insular Eskimo Population Group¹

From the Division of Research Grants, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland

Abstract

An epidemic of Influenza A-2 virus infection occurred in an isolated Eskimo population in November of 1957. This was studied serologically, using pre- and postepidemic sera from 183 of the people involved. Approximately 40% of the population had been given a small dose of A-2 influenza vaccine after onset of the epidemic. The general quantitative serologic reaction found post-epidemically in the vaccinated group was significantly lower than that found in unvaccinated, naturally infected individuals. The data did not prove that intercurrent vaccination prevented infection, but did suggest strongly that it altered the morbidity rate and also that it interfered with serologic response to the epidemic virus.

Footnotes

¹ Portions of the data presented here were previously discussed in the Medicine and Public Health Section, 9th Alaska Science Conference, College, Alaska, September 1958.

² At the time this work was accomplished, the author was a member of the staff of the Arctic Health Research Center, Division of General Health Services, Bureau of State Services, Public Health Service, Department of Health, Education and Welfare.