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An Inhibitor of Adenoviruses in OX Serum¹

From the Departments of Preventive Medicine, Pediatrics and Medicine, Western Reserve University School of Medicine: University Hospitals and Cleveland Metropolitan General Hospital, Cleveland, Ohio

Abstract

The presence of pooled, heated on serum in media inhibited the propagation of several types of adenovirus in HeLa cell tissue cultures. The greatest decrease in infectivity titer occurred with types 4, 5 and 7 adenoviruses. The inhibitor in normal ox serum was a heat-stable globulin which formed a nondissociable complex with the infectious virus particle and was not destroyed by RDE or trypsin. Although this inhibitor has many characteristics of neutralizing antibody, the observation that absorption of ox serum with type 3 adenovirus removed the inhibitor against both types 3 and 4 adenoviruses to a similar extent indicates that the inhibitor is not a mixture of several types of neutralizing antibody.

Footnotes

¹ This investigation was conducted under the sponsorship of the Commission on Acute Respiratory Diseases, Armed Forces Epidemiological Board, and supported by the Office of The Surgeon General, Department of the Army, and by grants from the Brush Foundation, the Robert Hamilton Bishop, Jr. Endowment Fund, the Republic Steel Corp., and the United States Public Health Service (No. E-1075).

² Present address: University of Pennsylvania, Philadelphia, Pennsylvania.