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Antibody Response of Adult Chickens to Infectious and Noninfectious Foot-and-Mouth Disease Virus

From the Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, United States Department of Agriculture, Greenport, Long Island, New York

Abstract

Lesions suggestive of infection were observed in or on the mouth, combs and feet of chickens inoculated with Type A-119 virus propagated in tissue culture. Lesions were not observed in chickens inoculated with Type A-GB virus propagated in guinea pig footpads.

A high titer of neutralizing antibody was induced in adult chickens by inoculation of 1 and 2 ml of either infectious or noninfectious Type A-119 virus grown in tissue culture. Infectious Type A-GB, propagated in guinea pig pads, produced a relatively low titer of neutralizing antibody in chickens.

Both strains, 119 and GB, of infectious Type A virus produced a good response of complement-fixing antibody in chickens as tested by a modified direct complement fixation test.

No evidence of infection was found in normal chickens held with infected birds in the same cage.