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Studies on the Coliphage Neutralizing Activity of Normal Human Serum

From the Department of Microbiology, Yale University Medical School, and the Howard Hughes Medical Institute, New Haven, Connecticut

Abstract

1. The ability of normal human serum to neutralize the coliphages T2, T4, T6 or T7 was either abolished or markedly depressed by heat treatment, decomplementation, absorption with zymosan, or removal of divalent cations from the serum.

2. The phage neutralizing activity of normal serum was inhibited by irradiated phage preparations. The inhibition produced was always greater in homologous systems than with heterologous ones. This would indicate that the normally occurring phage neutralizing substances exhibit some degree of serologic specificity.

Footnotes

¹ Present address: Plum Island Animal Disease Laboratory, U. S. Department of Agriculture, Greenport, Long Island, New York.