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Studies of Antisera to Adult Human Hemoglobin

From the Department of Pathology and the Physiological Laboratory, Cambridge, England

Abstract

1. Of 20 rabbits immunized with adult human hemoglobin, 10 eventually gave good precipitating antisera, 5 gave weak antisera and 5 had not produced precipitins after three courses of injections.

2. When mixed with hemoglobin all the antisera gave red precipitates and were able to precipitate completely adult and cord blood hemoglobin in optimal proportions or antiserum excess.

3. The antisera did not agglutinate human red cells.

4. Three of six antisera tested were able to annul the action of carbonic anhydrase.

5. Absorption experiments with two antisera showed a serological distinction between the major hemoglobin components of a cord blood and an adult blood.

6. Reactions of the antisera suggest the presence of two or more antigenically distinct hemoglobins in a single sample of blood from one adult.