HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Isacson, P. Articles by Hsiung, G. D. Search for Related Content PubMed Articles by Isacson, P. Articles by Hsiung, G. D.

Studies of a Myxovirus Isolated from Human Blood

III. Serologic Reactions in Persons with Viral Hepatitis¹

From the Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut

Abstract

1. Serologic responses to the DA virus were investigated in cases of human viral hepatitis from two sources; an epidemic of infectious hepatitis occurring among U. S. Naval personnel stationed in the Naples area, and human volunteer recipients of known infectious hepatitis virus, strain Akiba.

2. Antibodies to the DA virus as measured by hemagglutination-inhibition or neutralization of infectivity were more common in jaundiced cases from the Naples epidemic than from comparable controls, and 4-fold or greater rises in hemagglutination-inhibition titers were found in serial sera from 9 of 26 cases. No changes in titer using these tests were found in serial sera from Akiba recipients.

3. Sera from jaundiced cases from the Naples epidemic and sera from Akiba recipients were shown to possess the ability to agglutinate chick erythrocytes treated with the DA virus (anti-CSA).

4. In sera from the Naples epidemic, the anti-CSA was found to most closely resemble an antibody against DA viral antigen which had been deposited on the treated erythrocytes.

5. The anti-CSA in Akiba recipient sera was found to most closely resemble an antibody against erythrocytes which had been antigenically modified by the action of RDE from either bacterial or viral sources.

Footnotes

¹ Aided by a grant from the National Foundation and conducted under the suspices of the Commission on Viral Infections of the Armed Forces Epidemiology Board and supported in part by the Office of the Surgeon General, Department of the Army.

² Present address: Department of Microbiology, Yale University School of Medicine New Haven, Connecticut.