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The Inhibition of Hemagglutinin Formation in Mice by Purine and Pyrimidine Analogues¹

From the Department of Bacteriology, University of Oregon Medical School Portland, Oregon

Abstract

Screening experiments with 30 selected purine and pyrimidine analogues have revealed five compounds which inhibited hemagglutinin production in mice. Of these, 6-mercaptopurine, 6-mercaptopurine riboside, 2-amino-6-benzylmercaptopurine and 2-amino-6-(1'-methyl-4'-nitroso-5'-imidazoyl) mercaptopurine were classed as slightly active. One of the compounds, thioguanine, was found to be highly active in toxic doses. 6-mercaptopurine did not inhibit hemagglutinin formation in rabbits given a dose of 6 mg/kg for 13 days when either human or sheep red blood cells were used as antigen. In groups of mice also, 6-MP, at a dose level of 25 mg/kg, failed to prevent hemagglutinin formation. Thioguanine, however, in doses of 5 and 2.5 mg/kg, but not 1 mg/kg, blocked primary hemagglutinin production. With single animals, the inhibiting effect of thioguanine was uniformly evident; with 6-MP, variations were observed among individual mice. The data are discussed in relation to previously published studies on 6-MP.

Footnotes

Supported by Grant E-2661 (C₂) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Services.