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The Passive Transfer to Normal Dogs of Skin Reactivity, Asthma and Anaphylaxis from a Dog with Spontaneous Ragweed Pollen Hypersensitivity¹

Allergy Unit, Department of Medicine, Northwestern University Medical School, Chicago, Illinois

Abstract

The spontaneous ragweed pollen hypersensitivity disease of a dog has been passively transferred to normal dogs. Wheal and erythema type skin reactivity, asthma and anaphylaxis were transferred by a heat labile serum factor. Extravasation of Evans blue dye in reactive sites in passively sensitized skin sites increased visibility of the Prausnitz-Küstner reactions. Postmortem examination of dogs dying of anaphylaxis showed marked changes in the liver and intestines.

Footnotes

This investigation was supported by Research Grant No. E-1358 from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service.

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