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Studies of Viruses of the Tick Borne Encephalitis Complex

II. Disease and Immune Responses in Man Following Accidental Infection with Kyasanur Forest Disease Virus

Department of Virus Diseases, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

Abstract

Three overt human infections with Kyasanur Forest disease (KFD) virus directly related to laboratory contact are described. Each case was proved serologically, and in two KFD virus was isolated from blood. The epidemiologic association with laboratory exposure is described, and complete immunologic investigation of all potentially infected persons was made to determine the etiology of observed disease. Differences in serologic response to active disease, modified disease, and subclinical infection are presented. This study provides additional interpretable information concerning the significance of heterologous antibodies to subsequent infection with other Group B arthropod borne viruses.

Footnotes

¹ Present Addresses: L. J. M., Department of Medicine, Saint Vincents Hospital, Worcester, Massachusetts; C. F. N., United States Army Medical Research Unit, Institute for Medical Research, Kuala Lumpur, Malaya.

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