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The Journal of Immunology, 1962, 88: 217-220.
Copyright © 1962 by The American Association of Immunologists, Inc.

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Studies on Helminth Immunity

IV. Rapid Onset of Resistance by the White Mouse Against a Challenging Infection with Eggs of Hymenolepis Nana (Cestoda: Hymenolepididae)1

Donald Heyneman2

Department of Zoology, University of California, Los Angeles, California

Abstract

The time interval between initial infection with eggs of Hymenolepis nana and onset of a protective host reaction against a challenge with the same parasite has been restudied.

These findings confirm earlier reports of an extremely rapid onset of immunity to H. nana. It is concluded that a local, rapidly mobilized antibody reaction by the immediate cells affected could be responsible in spite of the brief period involved. If this can be proved immunologically, it would provide interesting evidence supporting the concept that locally concentrated cellular antibodies are an important host response to tissue invasion by helminths.

Footnotes

1 The opinions and statements contained herein are the private ones of the writer and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large. These studies were supported in part by a contract between the Office of Naval Research, Department of the Navy, and the University of California, Los Angeles, under Contract Nonr-233(56).

2 On special leave of absence as Head, Department of Parasitology, and Co-director, Sudan Subunit, United States Naval Medical Research Unit Number Three, American Embassy, Cairo, Egypt, U.A.R.







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