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Observations on the Nature of the Antigen in Tanned Red Cell Hemagglutination^1,2,

Departments of Medicine and Bacteriology, The University of Rochester, School of Medicine and Dentistry, Rochester, New York

Abstract

Egg albumin treated with 6 M urea has been shown to coat sheep red blood cells in such a way as to render them susceptible to hemagglutination by anti-egg albumin sera. Untreated egg albumin appears to do so poorly or not at all. It is suggested that the increased effectiveness of urea-treated egg albumin solutions to coat tanned cells effectively is related to partial denaturation of a portion of the egg albumin molecules, and it is emphasized that other proteins may behave similarly to egg albumin in this respect.

A limitation in using precipitin techniques for defining the specificities of hemagglutination reactions has been discussed.

Footnotes

¹ Supported by Research Grant U.S.P.H.S. A-2443 of the National Institutes of Health.

² Presented in preliminary form to the American Association of Immunologists, April, 1959.