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Studies of Anaphylaxis: Effect of Decomplementation with Aggregated -Globulin¹

Department of Medicine, Columbia University College of Physicians and Surgeons and the Edward Daniels Faulkner Arthritis Clinic of Presbyterian Hospital, New York City, New York

Abstract

The intravenous administration of aggregated human -globulin (AHGG) to guinea pigs depressed serum complement (C') levels and resulted in diminished responses to passive cutaneous anaphylaxis (PCA). The data suggest that C' may, under some circumstances, mediate PCA. Modification of passive systemic anaphylaxis by AHGG appeared not to be mediated by its anticomplementary effect.

Footnotes

This work was supported in part by grants from the U. S. Public Health Service and The National Foundation.

² John and Mary R. Markle Scholar in the Medical Sciences.

³ Student Fellow supported by the New York Chapter, Arthritis and Rheumatism Foundation.