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Biological Properties of the Cross-Reactions between Anti-BSA and Heterologous Albumins¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Abstract

The in vivo reaction between rabbit anti-BSA and cross-reacting serum albumins produced systemic anaphylaxis, passive cutaneous anaphylaxis, and the Arthus phenomenon. In some situations, the biological effects produced by the cross-reactions were comparable to the biological effects produced by the homologous reaction, provided that the amount of cross-reacting antibody involved in the cross-reactions was the same as the amount of antibody involved in the homologous reactions. To obtain biological effects with the cross-reactions of severity comparable to the effects obtained with the homologous reaction, larger amounts of the cross-reacting antigens were required than of the homologous antigen. As judged by the in vitro and in vivo properties of the BSA-anti-BSA reaction and the cross-reactions, it appeared that the cross-reactions were usually less avid than the homologous reaction.

Footnotes

Supported by the U.S.P.H.S. Grant No. E-3092 and the Atomic Energy Commission Contract No. AT (30-1) 1205. Recorded as Publication No. 278 of the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Presented in part at the 44th meeting of the American Association of Immunologists, Chicago, Illinois, April 1960.

² Senior Research Fellow of the National Institutes of Health. Present address: Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif.