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Actively Acquired Tolerance to Dinitrochlorobenzene¹

Department of Dermatology of the New York University Post-Graduate Medical School and the Skin and Cancer Unit University Hospital, New York, New York

Abstract

Experiments were designed to block or reduce the ability of guinea pigs to respond immunologically to 2,4-dinitrochlorobenzene (DNCB), i.e., to induce actively acquired tolerance to DNCB through prenatal exposure. This was accomplished by means of intraperitoneal injections of DNCB in pregnant guinea pigs. The effects of the in utero exposure were assessed in 264 guinea pigs born to mothers who, during pregnancy, had received DNCB in acetone or, for control purposes, acetone alone.

Actively acquired tolerance manifested itself by a diminished degree of allergic hypersensitivity to DNCB following postnatal sensitizing exposures in the offspring of mothers injected with DNCB as compared with the offspring born to "control" mothers.

Actively acquired tolerance was shown to be a specific phenomenon since there was no impairment in the capacity of the offspring exposed to DNCB in utero to undergo postnatal sensitization to citraconic anhydride, an allergen chemically unrelated to DNCB, as compared with guinea pigs born to "control" mothers. Actively acquired "cross-tolerance" was shown between DNCB and 2,4-dinitrofluorobenzene.

Footnotes

This study was supported by a grant from the United States Public Health Service (E-1361 (C4) (C5)).

This article has been cited by other articles:

				J. R. Frey, H. Geleick, and A. De Weck Immunological Tolerance Induced in Animals Previously Sensitized to Simple Chemical Compounds Science, May 15, 1964; 144(3620): 853 - 854. [Abstract] [PDF]